3-INDOLINE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC AND NEUROLOGIC DISORDERS.

摘要

The present invention relates to the use of a compound having the general formula wherein R1 is acyl, thioacyl, trifluoromethylsulfonyl or R1 is a group R12SO2-, R12OCO- or R12SCO- wherein R12 is C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-8-cycloalkyl, C3-8-cycloalkyl-C1-6-alkyl or aryl, or R1 is a group R13R14NCO,- R13R14NCS-, wherein R13 and R14 are independently hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-8-cycloalkyl, C3-8-cycloalkyl-C1-6-alkyl or aryl, or R13 and R14 together with the N-atom to which they are linked form a pyrrolidinyl, piperidinyl or perhydroazepin group; n is 1-6;X is C, CH or N, and the dotted line emanating from X indicates a bond when X is C and no bond when X is N or CH;R , R and R2 are independently selected from hydrogen and C1-6-alkyl;R3-R11 are independently selected from hydrogen, halogen, cyano, nitro, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-8-cycloalkyl, C3-8-cycloalkyl-C1-6-alkyl, amino, C1-6-alkylamino, di-(C1-6-alkyl)amino, C1-6-alkylcarbonyl, aminocarbonyl, C1-6-alkylaminocarbonyl, di-(C1-6-alkyl)aminocarbonyl, C1-6-alkoxy, C1-6-alkylthio, hydroxy, trifluoromethyl, trifluoromethylsulfonyl and C1-6-alkylsulfonyl; or a pharmaceutically acceptable acid addition salt thereof, for the manufacture of a medicament useful in the treatment of psychiatric and neurologic disorders, in particular psychoses.