PREPARATION METHOD OF ALIBENDOL

摘要

PURPOSE: A method for preparing alibendol is provided, to reduce remarkably a manufacturing cost by using 2-methoxy-4-(2-propenyl)phenol (eugenol) as a starting material. CONSTITUTION: The method comprises the steps of reacting the 2-methoxy-4-(2-propenyl)phenol represented by the formula 2 with an alkali metal base to activate the compound and reacting the activated compound with carbon dioxide to prepare the 2-hydroxy-3-methoxy-5-(2-propenyl)benzoic acid represented by the formula 3; and reacting the compound of the formula 3 with ethanolamine to prepare the alibendol represented by the formula 1, wherein M is an alkali metal. Preferably the alkali metal base is an alkali metal alkoxide, the activation reaction is carried out at a temperature of -20 to 100 deg.C, and the carbon dioxide addition reaction is carried out at a temperature of 50-200 deg.C and a pressure of 1-20 atm.