Telocinobufagin (TCINO) in the Diagnosis and Pathogenesis of Preeclampsia, Traumatic Brain Injury and Acute Respiratory Distress Syndrome

摘要

Certain embodiments are directed to methods of identifying patients with PE, TBI, or ARDS by detecting elevated levels of MBG, TCINO, and CINO and treating the same with anti-MBG agents.

主权项

1. A method for assessing patients for PE, TBI, or ARDS comprising (a) contacting a patient sample with a first binding reagent that specifically binds marinobufagenin (MBG) and a second binding reagent that specifically binds TCINO; (b) detecting and quantitating MBG-binding reagent complexes and TCINO-binding reagent complexes; and (c) classifying a patient as having PE, TBI, or ARDS if MBG, TCINO, or MBG and TCINO levels are elevated.