Cosmetic or dermatological compositions for preventing or treating skin inflammation, comprises oligogalacturonides having cellular recognition and adhesion inhibiting action

摘要

The use of oligogalacturonides (I) is claimed in the production of cosmetic, dermatological or pharmaceutical compositions for preventing or treating inflammation, especially of the skin. An independent claim is included for a cosmetic care method for sensitive skins, involving application of (I) to the skin to restrict the propagation of inflammatory response. ACTIVITY : Antiinflammatory; Dermatological; Antiallergic. MECHANISM OF ACTION : Inhibition of expression of cellular adhesion factors on dermal endothelial cells; Inhibition of recognition of circulating cells by endothelial cells; Inhibition of diapedesis. In cellular adhesion tests using flow cytometry, the relative adhesion of lymphocytes to HskMEC.ST endothelial cells was 8 in the absence of test compound without oxidative stress, 15 in the absence of test compound under oxidative stress (incubation with 100 MicroM hydrogen peroxide), 7 in presence of 100 Microg/ml (I) without oxidative stress and 6 in presence of 100 Microg/ml (I) under oxidative stress.