| 发明名称 |
MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS |
| 摘要 |
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo. |
| 申请公布号 |
HK1151984(A1) |
申请公布日期 |
2017.03.10 |
| 申请号 |
HK20110106187 |
申请日期 |
2011.06.15 |
| 申请人 |
Seattle Genetics Inc. |
发明人 |
Svetlana O. DORONINA;Peter D. SENTER;Brian E. TOKI;Allen J. EBENS;Toni Beth KLINE;Paul POLAKIS;Mark X. SLIWKOWSKI;Susan D. SPENCER |
| 分类号 |
A61K;A61K38/00;A61K38/06;A61K39/395;A61K47/48;C07K;C07K16/46 |
主分类号 |
A61K |
| 代理机构 |
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