18-methyl-5alpha-h-androstanes anabolic agents

摘要

(A) Compds. (I): - where R = H or acyl - A-B = -CH2-CH2, -CH=CH-, =CH- - or - -CH2- and R' = H or acyl. - (B) Medicaments contg. (I). - Anabolic agents. - 15 g. (II; R=Ac) in 200 ml. Et2O/dioxane (1:1) added dropwise to 4.5 g. Li in 1500 ml. liquid NH3 at -70 deg.C, stirred 30 mins., 30 g. NH4Cl added over 30 mins., NH3 evapd., 500 ml. Et2O added, the soln. washed, dried and evapd., the residue chromatographed on SiO2 gel and eluted with hexane/Me2CO mixtures gave (I; A-B = CH2CH2, R = Ac) m 158.5-9.5 deg.C (iso-Pr2O).