发明名称 |
AGENTS AND METHODS TO ELICIT ANTI-TUMOR IMMUNE RESPONSE |
摘要 |
The invention provides an isolated, purified population of human cells comprising CD8+ T cells with reduced Cbl-b activity. The invention provides uses of such cells in methods for inducing or enhancing an anti-tumor immune response in a subject. These methods comprise: (a) providing a cell population, from a subject or from another source, which comprises CD8+ T cells, (b) reducing Cbl-b activity in the CD8+ T-cells, (c) administering the cells of step (b) to the subject. The invention provides methods for making CD8+ T cells that do not require stimulation through a co-receptor in order for the cell to become activated or proliferated in response to contact via its T cell receptor. Such methods are based upon reducing function of Cbl-b. The invention also provides methods for identifying agents which affect Cbl-b expression or activity. |
申请公布号 |
US2016312183(A1) |
申请公布日期 |
2016.10.27 |
申请号 |
US201615089016 |
申请日期 |
2016.04.01 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK ;The Government of the US as represented by the Secretary of the Department of Health and Human Se |
发明人 |
GU Hua;HODES Richard;CHIANG Jeffrey J.;JANG Ihnkyung |
分类号 |
C12N5/0783 |
主分类号 |
C12N5/0783 |
代理机构 |
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代理人 |
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主权项 |
1. An isolated, substantially purified, population of cells comprising CD8+ T cells with reduced Cbl-b activity. |
地址 |
New York NY US |