| 摘要 |
1428041 Digitoxin esters BOEHRINGER INGELHEIM GmbH 30 May 1973 [31 May 1972] 25852/73 Heading C2U The invention comprises digitoxin 3<SP>111</SP>-esters with R<SP>2</SP>CO 2 H where R<SP>2</SP> is C 2 -C 15 alkyl, halo- C 1 -C 4 alkyl, cyano-C 1 -C 4 alkyl, ethoxycarbonyl-C 1 -C 4 alkyl, phenyl-C 1 -C 4 alkyl, phenoxy-C 1 -C 4 alkyl (said phenyl and phenoxy moieties being optionally substituted), C 3 -C 6 cycloalkyl, (C 3 -C 6 cycloalkyl)methyl or (trifluoroacetamido)ethyl; and their preparation from digitoxin by esterification, either direct or via 3<SP>111</SP>,4<SP>111</SP>-(alkyl orthoesters). Cardiotonic compositions for oral, rectal and parenteral administration comprise a carrier and a compound of the invention. |
