| 摘要 |
FIELD: medicine.SUBSTANCE: invention relates to medicine, particularly to medical genetics and gynecological oncology and is created to prognosticate the risk of ovarian cancer. DNA is isolated from lymphocytes of peripheral venous blood and complex detection of mutations c.5266dupC (BRCA1), c.181T>G (BRCA1), del5395 (CHEK2) and p.R145W (CHEK2) of a patient. Detection of one of the mentioned mutations indicates high risk of ovarian cancer. Invention provides a simpler method of identification of mutations c.5266dupC, c.181T>G (BRCA1), del5395 and p.R145W (CHEK2).EFFECT: simplification of method of identification of mutations and reduction of research time to 1 day.1 cl, 4 dwg, 5 ex |
