METHODS FOR DIAGNOSING AND TREATING DIABETES

摘要

Methods and kits for diagnosing and treating type I diabetes based upon the expression of macrophage-specific Chymotrypsin-Like Elastase Family, Member 3B, either alone or in combination with sialic acid-binding immunoglobulin-like lectin-1, are provided.

主权项

1. A method for diagnosing a subject with type diabetes comprising
(a) obtaining a sample from the subject; (b) measuring the expression of Chymotrypsin-Like Elastase Family, Member 3B (CELA3B) and optionally sialic acid-binding immunoglobulin-like lectin-1 (SIGLEC-1) protein or nucleic acids encoding the same, in the sample; (c) comparing the expression of CELA3B and optionally SIGLEC-1 in the sample to the expression of CELA3B and optionally SIGLEC-1 in a control; and (d) diagnosing the subject with type I diabetes when the expression of CELA3B and optionally SIGLEC-1 in the sample from the subject is elevated compared to the expression of CELA3B and optionally SIGLEC-1 in the control.