| 摘要 |
The present invention relates to polypeptides comprising an amino acid sequence exhibiting at least about 90% sequence identity with the sequence of SEQ ID NO: 1. Said polypeptides preferably degrade the peptidoglycan of Gram-negative bacteria, in particular of Pseudomonas and/or Campylobacter bacteria. In addition, the present invention relates to nucleic acids encoding such polypeptides, vectors comprising such nucleic acids, and corresponding host cells. Finally, the present invention relates to compositions comprising such polypeptides, nucleic acids, vectors, and/or host cells according to the present invention. |
| 主权项 |
1. A polypeptide comprising the sequence of SEQ ID NO: 1, wherein SEQ ID NO: 1 is characterized by
X1 may be absent or any amino acid, in particular M, X120 may be any amino acid, in particular S or G X126 may be any amino acid, in particular A or E X128 may be any amino acid, in particular T or K X134 may be any amino acid, in particular W or I X135 may be any amino acid, preferably S X138 may be any amino acid, in particular H or L X171 may be any amino acid, in particular E or G X173 may be any amino acid, in particular Y or T X182 may be any amino acid, in particular A or T X187 may be any amino acid, in particular N or G X197 may be any amino acid, in particular D or S X198 may be any amino acid, in particular Q or A X204 may be any amino acid, in particular L or Y X230 may be any amino acid, in particular F or L X231 may be any amino acid, in particular H or Y X234 may be any amino acid, in particular S or A and wherein the polypeptide does neither comprise the amino acid sequence of SEQ ID NO: 2 nor of SEQ ID NO: 183, and wherein the polypeptide does not comprise an E155A mutation at position 155 of SEQ ID NO: 1. |
