| 摘要 |
<p>1,264,779. Ergoline derivatives. SPOFA. 28 Aug., 1970 [29 Aug., 1969], No. 41471/70. Heading C2C. Novel compounds I and their salts in which R 1 is H or 1-6C alkyl; and R 2 is H, 1-6C alkyl, 5-6C cycloalkyl, 3-4C hydroxyalkyl, or (1-4C alkoxy) carbonylmethyl; or NR 1 R 2 is a 5- or 6-membered heterocyclic ring are prepared by reacting the azide of D-6- methyl-8-ergolinyl-acetic acid or its hydrochloride with HNR 1 R 2 and optionally forming a salt from the resultant base. Pharmaceutical compositions comprise a compound I together with a suitable carrier and have antilactation and anti-fertility effects.</p> |
