发明名称 |
FORFARANDE FOR FRAMSTELLNING AV VISSA INDANYLOXITETRAZOLER |
摘要 |
[1-Oxo-2-halo(or hydrogen)indanyloxy(or thio)]-alkanoic acid products and salts, esters and amide derivatives where the indanyl ring may be further substituted with from 2 to 5 nuclear substituents. The [1-oxo-2-haloindanyloxy-(or thio)]alkanoic acids are prepared (1) via the halogenation of a [1-oxoindanyloxy(or thio)]alkanoic acid or (2) via the addition of halogen to a [1-oxoindenyloxy(or thio)]-alkanoic acid. The [1-oxoindanyloxy(or thio)]alkanoic acids are prepared (1) via cyclialkylation of a (2-alkylideneacyl)-phenoxy(or thio)alkanoic acid or (2) via etherification of a hydroxy(or mercapto)-2-alkyl-1-indanone. The [1-oxo-2-halo(or hydrogen)indanyloxy(or thio)]alkanoic acids are diuretics and saluretics. In addition, some of these compounds are also able to maintain the uric acid concentration in the body at pretreatment level or to cause a decrease in uric acid concentration. |
申请公布号 |
SE392269(B) |
申请公布日期 |
1977.03.21 |
申请号 |
SE19720013847 |
申请日期 |
1972.10.26 |
申请人 |
MERCK & CO INC |
发明人 |
CRAGOE JR E J;WOLTERSDORF JR O W |
分类号 |
C07C45/46;C07C45/67;C07C45/71;C07C45/74;C07C45/75;C07C49/747;C07C49/84;C07C59/86;C07C59/88;C07C59/90;C07D257/04;(IPC1-7):07D257/04 |
主分类号 |
C07C45/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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