发明名称 |
USE OF LOW TEMPERATURE AND/OR LOW PH IN CELL CULTURE / PH |
摘要 |
The present invention provides a novel method of reducing protein misfolding and aggregation in the cell culture by growing the cell culture at a reduced temperature and/or reduced pH. As a result, the quality of the protein produced in the cell culture is greatly improved. Thus, the present invention facilitates improvements in the efficacy of therapeutic proteins produced in cell culture. |
申请公布号 |
HK1216261(A1) |
申请公布日期 |
2016.10.28 |
申请号 |
HK20160104245 |
申请日期 |
2016.04.13 |
申请人 |
WYETH |
发明人 |
GOMES, Jose, Manuel;HILLER, Gregory, Walter |
分类号 |
C12P |
主分类号 |
C12P |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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