Metallic nanoparticles and methods for their preparation and use

摘要

Provided herein are Raman active particles and methods for their preparation and use. The particles can include a SERS-active material that is at least partially encased within a spherical porous hollow casing. In some embodiments, this can be especially advantageous when employed for water analysis and/or being employed in combination with silica particles.

主权项

1. A method of preparing a Raman active particle, the method comprising:
providing a spherical polystyrene particle; adsorbing a SERS-active material onto the surface of the spherical polystyrene particle by electrostatic adsorption to form a SERS-active nanoparticle; coating the SERS-active nanoparticle with a dissolvable material to form a coated SERS-active nanoparticle; processing the coated SERS-active nanoparticle with a silanizing component to form a mesoporous SiO2 containing shell structure over at least a portion of the SERS-active nanoparticle; and adding a solvent to dissolve and remove the dissolvable material to obtain a SERS-active nanoparticle within a porous SiO2 hollow shell, thereby preparing a Raman active particle.