发明名称 |
4-Benzamido-biphenyl-4'-oxy-propionic acids and related cpds. - have hypocholesterolemic and hypotriglyceremic activity |
摘要 |
<p>Biphenyloxy cpds of formula (I) and their salts with mineral or org. bases when R3=carboxy. (where R1=opt. branched 1-6C alkyl, 3-6C cycloalkyl or phenyl (opt. substd. alkyl), phenylalkyl, phenylalkenyl or pyridyl, R2=H or 1-4C alkyl, R3= hydroxymethyl, carboxy, 2-7C alkoxycarbonyl or 4-8C cycloalkoxycarbonyl, A=-CONH- or -NHCO-, n=1,2 or 3) have superior hypocholesterolemic and hypotriglyceremic activity to cpds. described in DT 2149070, GB 860303 and GB 112172. They are generally administered orally or rectally as unit doses of 5-100 mg (pref. 5-30 mg) to give a daily dose of 10-300 mg (pref. 15-90 mg). Tests show ED to lower serum cholesteral by 20%, compare favourably with known cpds.</p> |
申请公布号 |
DE2547872(A1) |
申请公布日期 |
1977.05.05 |
申请号 |
DE19752547872 |
申请日期 |
1975.10.25 |
申请人 |
DR. KARL THOMAE GMBH |
发明人 |
GRISS,GERHARD,DIPL.-CHEM.DR.;GRELL,WOLFGANG,DIPL.-CHEM.DR.;HURNAUS,RUDOLF,DIPL.-CHEM.DR.;SAUTER,ROBERT,DIPL.-CHEM.DR.;EISELE,BERNHARD,DIPL.-CHEM.DR.;KAUBISCH,NIKOLAUS,DIPL.-CHEM.DR.;LEITOLD,MATYAS,DR. |
分类号 |
C07D213/82;(IPC1-7):C07C103/30 |
主分类号 |
C07D213/82 |
代理机构 |
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地址 |
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