Nicotinoylcarnitine derivs - having prolonged anti-lipaemic activity

摘要

Nicotinoylcarnitine deriv. (I), where R is lower alkoxy, benzyloxy, amino; X is -OH, acid residue is prepared by reacting carnitine deriv. (II) with nicotinoylating agent (reactive deriv. on the carboxyl gp. of nicotinic acid, eg. nicotinic anhydride, nicotinic acid halide). The prods. have lower hydrogscopicity and are drugs having prolonged anti-lipaemic activity.