| 摘要 |
<p>Compsn. consists of a soln. or microcrystalline suspension of cardiac glycosides (I) in partial glycerides (II) of medium chain-length fatty acids, or mixts. of glycerides. Pref. (II) are mono-and/or di-glycerides and the acid component has 6-12, esp. 8-10C. Suitably the compsns. are treated with an auxiliary to increase the viscosity or give it structure, and then filled into a gelatin capsule, opt. coated with a substance resistant to gastric acid. alternatively they are made up as suppositories. Compsn. is used for treatment of cardiac insufficiency. Compsns. has very high (=80%) enteric resorption for (I) which are normally very difficulty resorbable, e.g. strophanthin g or k, and proscillaridine. LD50's are lower in (II), e.g. for strophanthin g it is 5.2 mg/kg c.f. 34.8 mg-kg in water (orally in guinea pigs).</p> |
