13-CIS PROSTAGLANDIN DERIVATIVES AND METHODS OF MAKING

摘要

13-Cis prostaglandin derivatives; cis-octenol ether copper (I) lithium reagents and methods of making such reagents and using the reagents to prepare the 13-cis prostaglandin derivatives. The 13-cis prostaglandin derivatives exhibit prostaglandin-like pharmacological properties and are further useful as intermediates for the corresponding prostaglandin isomers having the normal 13-trans configuration.