FREMGANGSMAATE VED FREMSTILLING AV PEPTIDER

摘要

Peptide derivatives, which are intermediates in the preparation of thymosin alpha 1 and [Asn<2>]-thymosin alpha 1, of the general formula H3C-CO-Ser(R<1>)-X-Ala-Ala-Val-Asp(OR<2>)-Thr(R<3>)-Ser(R<1>)-Ser(R<1> )-Glu(OR <4>)-I le-Thr(R<3>)-Thr(R<3>)-Lys(R<5>)-Asp(OR<2>)-Leu-Lys(R<5>)-Glu(OR<4>)-L ys(R <5 )-Lys(R<5>) -Glu(OR<4>)-Val-Val-Glu(OR<4>)-Glu(OR<4>)-Ala-Glu(OR<4>)-Asn-OR<6) in which X represents Asn or Asp(OR<2>); R<1> represents a group which can be removed with formation of the hydroxyl group of the seryl radical; R<2>, R<4> and R<6> represent a group which can be removed with formation of a carboxyl group; R<3> represents a group which can be removed with formation of the hydroxyl group of the threonyl radical and R<5> represents a group which can be removed with formation of the omega -amino group of the lysyl radical.