1,3-DIOXO-2-ISOINDOLINEACETIC ACID, /N-(2-BENZOYL-PHENYL)-1,3-DIOXO-2-ISOINDOLINEACETAMIDO METHYLENE/HYDRAZIDES

摘要

A multistep process is disclosed for the production of a compound of the formula V: V wherein R' and R" are alkyl of 1 to 3 carbon atoms, inclusive or together is pyrrolidino, piperidino, 4-methylpiper-azino or morpholino; and wherein the rings A and B are unsubstituted, or substituted by one or more substituents selected from the group consisting of fluoro, chloro, bromo, nitro and trifluoromethyl. Compounds of formula V are used for treatment of anxieties and/or depressions in mammals and birds. This divisional application is directed to the production of intermediate compounds of the formula II: wherein R1 is hydrogen or halogen. The process comprises treating one mole of a compound of the formula in an inert organic solvent with two mole equivalents of .alpha.-phthalimidoacetyl chloride or bromide in the presence of a base at -5.degree. to 15.degree.C.