| 摘要 |
A new diagnostic labeled spine tool is disclosed for use in immunoassay techniques, e.g., determination of a component of the antigen-antibody reaction. The new tool is a labeled-spine material product of the formula <IMAGE> (XVI) where R is an organic group labeled with a radioisotope, fluorescent group, lysis-initiating compound, enzyme, or other suitable marker material; T1 and T2 are any of -CH3, <IMAGE> -CH2OH, -Ch2SH, and -NH2; X is selected from the group consisting of (CH2)m, where m is an integer from 0 to about 10, phenylene, hydroxyl-substituted phenylene, halogen-substituted phenylene, alkyl substituted phenylene or aminated phenylene groups; A IS 0, 1 OR 2; B IS 2-A, WITH THE PROVISO THAT THERE BE AT LEAST TWO R groups in the product; and N IS A NUMBER FROM 1 TO ABOUT 100,000 The new tool provides higher specific activity for labeled substances thus facilitating determination of the desired compound. Preferably R is an enzyme, a is one, and X is of the formula (CH2)m, where m is from 2 to 5.
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