| 摘要 |
The invention relates to substituted 1-thienyl- and 1- furyl-2,3,4,5-tetrahydro-1H-3-benzazepines with two hydroxyl substituents in the benzene ring of the benzazepine nucleus, these compounds having a dopaminergic activity. The invention also relates to a process for the preparation of these compounds, which have the formula <IMAGE> (where R is a hydrogen atom, a benzyl or phenylethyl group, a lower alkanoyl group with 1-5 carbon atoms, a lower alkyl group with 1-5 carbon atoms, a hydroxyalkyl group or a lower alkenyl group with 3-5 carbon atoms; R1 is a hydrogen or halogen atom or a trifluoromethyl, methylthio, trifluoromethylthio, methyl or methoxy group; R2 and R3 are hydrogen atoms, lower alkyl groups with 1-5 carbon atoms, lower alkanoyl groups with 2-5 carbon atoms, or jointly methylene or ethylene groups; R4 is a hydrogen or halogen atom, a cyanomethyl, methyl or carbomethoxy group; and X stands for -O- or -S-). The invention also relates to pharmacologically acceptable non-toxic salts of these compounds, together with pharmaceutical compositions containing them. |
