| 摘要 |
The Isatin derivatives are compounds having the formula:- …<CHEM>… wherein R<1> and R<2> are each hydrogen, halogen, lower alkyl, lower alkoxy, halo(lower)-alkyl, acylamino or heterocyclic group containing at least one imino group, or… R<1> and R<2> are combined together to form a benzene ring,… R<3> is oxo or a group of the formula: = N-OR<5>, in which R<5> is hydrogen or lower alkyl,… R<4> is hydrogen; ar(lower)alkyl optionally having halogen, carboxy or esterified carboxy; aryl optionally having halogen; acyl; or 10, 11-dihydro-5H-dibenzo[a, d]- cycloheptenyl,… A is lower alkylene optionally having hydroxy and… Y is (C1 to C3) alkylene,… and their pharmaceutically acceptable salts. The compounds are prepared by the reaction of isatin or its substituted derivatives with suitable substituent group-containing compounds. …<??>Pharmaceutical compositions containing the isatin derivatives of their pharmaceutically acceptable salts are useful for treating allergic symptoms. |
