发明名称 |
MODULATING URACIL-DNA GLYCOSYLASE AND USES THEREOF |
摘要 |
The present invention concerns a method for the prevention and/or treatment of an activation-induced deaminase (AID)-associated disease in a subject in need thereof, said method comprising administering an effective amount of an uracil-DNA glycosylase (UNG) inhibitor, or a composition comprising the inhibitor, and a pharmaceutically acceptable carrier, to a subject having pathogenic cells expressing AID, uracil-DNA glycosylase (UNG) and mismatch repair pathway (MMR). Also provided are kits comprising an UNG inhibitor, methods of stratifying a subject having an AID-associated disease, uses and compositions for use of the UNG inhibitor. |
申请公布号 |
WO2016172795(A1) |
申请公布日期 |
2016.11.03 |
申请号 |
WO2016CA50486 |
申请日期 |
2016.04.27 |
申请人 |
ADAERATA LIMITED PARTNERSHIP;UNIVERSITY OF MIAMI |
发明人 |
DI NOIA, Javier M.;VERDUN, Ramiro E.;METHOT, Stephen Patrick |
分类号 |
A61K38/16;A61K31/395;A61K35/76;A61K38/15;A61P35/00;A61P35/02;C07D225/06;C07K11/02;C07K14/32;C12Q1/00;G01N33/48 |
主分类号 |
A61K38/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|