The present invention relates to methods for diagnosing, monitoring or prognosticating prostate cancer or the progression state of prostate cancer wherein said method determines the state of the prostate cancer, based on the expression level of phosphodiesterase 4D (PDE4D) variants. The invention further relates to a method of identifying an individual for eligibility for prostate cancer therapy. The invention also relates to products for the analysis of phosphodiesterase 4D (PDE4D) variants as well as pharmaceutical compositions modulating the activity and/or expression of PDE4D variants.
申请公布号
WO2016193110(A1)
申请公布日期
2016.12.08
申请号
WO2016EP61886
申请日期
2016.05.26
申请人
KONINKLIJKE PHILIPS N.V.
发明人
HOFFMANN, Ralf;DEN BIEZEN - TIMMERMANS, Eveline;VAN STRIJP, Dianne Arnoldina Margaretha Wilhelmina;VAN BRUSSEL, Anne Godefrida Catharina;ALVES DE INDA, Márcia;WROBEL, Janneke