| 摘要 |
PURPOSE:An antitumorigenic agent that is made by adding a uracil to a specific fluoro compound whereby the antitumorgenic activity of the fluoro compound is extremely increased and the toxicity becomes low. CONSTITUTION:Ethyl 6-n-butoxy-5-fluorohexahydro-2,4-dioxopyrimidine-5-carboxylate (abbreviated to fluoro compound hereinafter) is combined with at least one selected from uracils consisting of uracil, thymine and thymidine to give the antitumorigenic agent. The amount of the uracil is preferably 0.5-100mol/mol of the fluoro compound. Although a uracil itself has no antitumorigenic activity, the combination with the fluoro compound markedly increase the effect of the compound. Further, the titled antitumorigenic agent scarcely develops toxicity. |
