| 发明名称 |
Adenovirus Expressing Immune Cell Stimulatory Receptor Agonist(s) |
| 摘要 |
Certain embodiments include the enhancement of effectiveness for an adenoviral cancer therapy. |
| 申请公布号 |
US2016289645(A1) |
申请公布日期 |
2016.10.06 |
| 申请号 |
US201415038446 |
申请日期 |
2014.11.21 |
| 申请人 |
DNATRIX, INC. ;THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
TUFARO Frank;FUEYO-MARGARETO Juan;GOMEZ-MANZANO Candelaria;CONRAD Charles;YUNG Alfred W.K.;JIANG Hong |
| 分类号 |
C12N7/00;A61K31/495;A61K38/21;A61K35/761;A61K45/06 |
主分类号 |
C12N7/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A replication competent oncolytic virus comprising a heterologous nucleic acid inserted into a nonessential region of the adenovirus genome, said nucleic acid comprising a sequence encoding an OX40 (CD134) agonist operatively linked to a transcriptional control element. |
| 地址 |
Houston TX US |
