| 发明名称 |
COMPOSITION AND METHODS OF GENOME EDITING OF B-CELLS |
| 摘要 |
The present invention provides methods compositions and methods of preparing autologous (or allogeneic) B cells that secrete a monoclonal of interest useful in immunotherapy or B cells with an altered function. |
| 申请公布号 |
US2016289637(A1) |
申请公布日期 |
2016.10.06 |
| 申请号 |
US201615161213 |
申请日期 |
2016.05.21 |
| 申请人 |
Dana-Farber Cancer Institute, Inc. |
发明人 |
GOLDBERG Michael;GREINER Vera |
| 分类号 |
C12N5/0781;C12N15/90;C07K16/24;C12N15/10 |
主分类号 |
C12N5/0781 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated human B cell, comprising one or more genomic modifications wherein said B cell (i) expresses a defined protein of interest or (ii) does not express one or more endogenous proteins. |
| 地址 |
Boston MA US |
