发明名称 NOVEL STILBENE DERIVATIVE, ITS PREPARATION, AND MEDICAL COMPOSITION CONTAINING THE SAME AS ACTIVE INGREDENT
摘要 NEW MATERIAL:A stilbene derivative of formulaI(X1, X2 are H, halogen; A is straight-chain or branched-chain alkylene; R1 is alkyl, cycloalkyl; R2 is H, alkyl) and its pharmaceutically permissible salts. EXAMPLE:Methyl 4-(1-methyl-2-phenylvinyl)phenylacetate. USE:Anti-inflammatory, analgesic or antipyretic, which is used as remedy for arthritis, rheumatism and neuralgia. PREPARATION: The reaction between a compound of formula II and another compound of formula III (X3 is halogen) in the presence of a strong base is, when necessary, followed by hydrolysis of the product and conversion to its salt to produce the compound of formulaIor its pharmaceutically permissible salt.
申请公布号 JPS5764639(A) 申请公布日期 1982.04.19
申请号 JP19800139160 申请日期 1980.10.04
申请人 NIHON ZOUKI SEIYAKU KK 发明人 HAMADA MASAAKI;OKAMOTO KAORU;KUROSAKI TEIKICHI
分类号 C07C69/618;A61K31/19;A61K31/215;A61P25/04;A61P29/00;C07C51/00;C07C51/347;C07C57/42;C07C57/48;C07C57/60;C07C57/62;C07C67/00;C07C69/65 主分类号 C07C69/618
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