Methods for Determining The Risk of Prenatal Complications

摘要

The disclosure relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual has for developing pre-eclampsia based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers. The disclosure also relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual is carrying a fetus having a chromosomal abnormality based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers.

主权项

1. A method for determining the risk of pre-eclampsia in a pregnant individual, comprising:
determining the amount of one or more biochemical markers selected from placental growth factor (PlGF) and pregnancy-associated plasma protein A (PAPP-A) in one or more blood samples from the individual; determining the blood pressure of the individual; and determining the risk of pre-eclampsia using the amount of each of the selected one or more biochemical markers and the blood pressure of the individual, wherein determining the risk comprises determining a likelihood ratio for blood pressure and calculating a final risk based on the individual's prior risk of developing pre-eclampsia and a set of likelihood ratios based on the amounts of the one or more biochemical markers and the blood pressure.