| 摘要 |
Compounds of the following general formula are testosterone 5 alpha -reductase inhibitors rendering said compounds useful in the treatment of acne and oily skin: <IMAGE> wherein n is an integer of from 0 to 4; R1 is -COOR2, -CONR3R4, -CHO or -CH2OR5; R2 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, or benzyl; each of R3 and R4 is hydrogen or a straight or branched lower alkyl group of from 1 to 4 carbon atoms; and R5 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched, or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms. |
