| 发明名称 |
SYNTHETIC PEPTIDE FOR REPRESSING TRANSCRIPTION AND/OR GENE EXPRESSION FROM A BINDING SITE OF INTEREST |
| 摘要 |
A synthetic peptide includes an amino acid sequence that: has 70-75%, 75-80%, 80-85%, 85-90%, 90-95% or 95-100% homology with an RpoN box of Region III of an RpoN protein; and binds specifically to a −24, −12, or −24/−12 site(s) of an RpoN promoter. The synthetic peptide is effective for repressing transcription and/or gene expression from a binding site of interest, and the binding site of interest is an RpoN binding site or a cryptic promoter upstream of an RpoN binding site. |
| 申请公布号 |
US2016362452(A1) |
申请公布日期 |
2016.12.15 |
| 申请号 |
US201615175589 |
申请日期 |
2016.06.07 |
| 申请人 |
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK |
发明人 |
NOMURA Christopher T.;LUNDGREN Benjamin R. |
| 分类号 |
C07K14/00 |
主分类号 |
C07K14/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A synthetic peptide comprising an amino acid sequence that:
(a) has 70-75%, 75-80%, 80-85%, 85-90%, 90-95% or 95-100% homology with an RpoN box of Region III of an RpoN protein; and (b) binds specifically to a −24, −12, or −24/−12 site(s) of an RpoN promoter, wherein said synthetic peptide is effective for repressing transcription and/or gene expression from a binding site of interest, wherein the binding site of interest is an RpoN binding site or a cryptic promoter upstream of an RpoN binding site. |
| 地址 |
Syracuse NY US |
