| 摘要 |
<p>/ABRIDGEMENT Novel 4-substituted imidazo¢1,2-.alpha.!quinoxalines having the general formula , wherein X is -R1 or -NHR2 , wherein (1) R1 is bonded to a ring carbon by a carbon-to-carbon linkage and is an aliphatic, cycloaliphatic, substituted phenyl, fused bicyclic aryl; or monocyclic aryl-substituted aliphatic; and (2) R2 is a radical bonded to a nitrogen by a carbon to nitrogen linkage; said radical being selected from the group consisting of aliphatic, cycloaliphatic, phenyl, substituted phenyl, fused bicyclic aryl or a monocyclic aryl-substituted aliphatic group; and pharmaceutically acceptable salts thereof are disclosed which have several uses such as immunosuppressants, antifungal agents and/or as anti-inflamatory agents. As disclosed are certain 1-(2-acylaminophenyl)imidazoles useful in the preparation of said 4-substituted imidazo ¢1,2-.alpha.!quinoxalines and the method of preparing the 4-substituted imidazo¢1,2-.alpha.!quinoxalines from said 1-(2-acylaminophenyl)imidazoles by use of a cyclizing agent, e.g. phosphorous oxychloride.</p> |
