| 摘要 |
<p>A reusable closure cap for sealing a vial, a method of making such closure cap, and methods of sealing a vial with such closure cap. The closure cap comprises a rigid tubular screw-type cover having as an integral part thereof a relatively soft, highly elastic stopper bonded at its top to the interior of the closed top end of the tubular cover. The elastic stopper has its top and a lower portion both larger in diameter than the inside diameter of the top opening of the vial, so as to enable an air and liquid tight seal. The bonding of the stopper to the cover and the sealing of the vial are both accomplished by: seating the stopper into the top of the vial, applying an adhesive to the top of the stopper, and screwing down the cover over the vial and stopper. An embodiment of the stopper and the sealing method is adapted for freeze-dry technology.</p> |
