| 摘要 |
<p>NEW MATERIAL:A compound of formulaI(X is halogen). EXAMPLE:Bis(5-chloro-8-quinolyl)-4-chlorophenyl phosphate. USE:A selective phosphorylating agent in the 5'-position of nucleosides, which are used in synthesis of artificial genes. In the molecule, it acts as a protecting group for phosphoric acid and contains eliminative groups. PREPARATION:The condensation reaction between 1-equivalent amount of 4- chlorophenyl phosphorodichloridate of formula II and 2-equivalent amount of 5-halogen-8-hydroxyquinoline is carried out in an organic solvent in the presence of a dehydrochlorinating reagent to give phosphoric triester of formula IV. Then, the triester is hydrolyzed to remove p-chlorophenyl group selectively, thus giving the objective compound of formulaI.</p> |
