| 发明名称 | Modified gram positive bacteria and uses thereof | ||
| 摘要 | The present invention relates to a gram positive bacterium, preferably a lactic acid bacterium (LAB) or Bifidobacterium, with increased stress resistance and/or improved manufacturing, processing and/or storage characteristics. In particular, the invention relates to a gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack trehalose 6-phosphate phosphorylase (TrePP) activity. The gram positive bacterium may further lack cellobiose-specific PTS system IIC component (ptcC) activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof. | ||
| 申请公布号 | US9458467(B2) | 申请公布日期 | 2016.10.04 |
| 申请号 | US201214346504 | 申请日期 | 2012.09.21 |
| 申请人 | INTREXON ACTOBIOTICS NV | 发明人 | Steidler Lothar;Van Huynegem Karolien;Vandenbroucke Klaas |
| 分类号 | A61K39/02;A01N63/02;A01N63/00;C12N1/20;C12N1/00;C12N15/74;C12N1/04;C12N9/10;A23L1/30;A61K38/00;A61K39/00;C07K14/325;C12N15/86;A61K35/744 | 主分类号 | A61K39/02 |
| 代理机构 | Drinker Biddle & Reath LLP | 代理人 | Drinker Biddle & Reath LLP |
| 主权项 | 1. A composition comprising a gram positive bacterium selected from a lactic acid bacterium (LAB) and a Bifidobacterium, the gram positive bacterium lacking trehalose 6-phosphate phosphorylase (TrePP) activity and cellobiose-specific PTS system IIc component (“ptcC”) activity, and pharmaceutically acceptable carrier. | ||
| 地址 | Zwijnaarde BE | ||