| 摘要 |
<p>The invention relates to a process for preparing an oxytetracycline composition, consisting alkaline earth metal complexes of oxytetracycline in a mixture of water, water miscible organic solvent and adjuvants. Said compositions are obtained by incorporating 10-30 parts by weight of oxytetracycline in the form of the base or an acid addition salt and sufficient alkaline earth metal ions to form a complex with the oxytetracycline, into 30-60 parts by volume of water, adding desired adjuvants and making up the mixture with N-methylpyrrolidone up to a volume of 100 parts by volume. Preferably 20-25 parts by weight of oxytetracycline in the form of the base or an acid addition salt are used and preferably magnesium oxide is used as source of alkaline earth metal ions. As one of the adjuvants preferably 2.5-10 parts by weight of polyvinylpyrrolidone are used.</p> |
