| 摘要 |
PURPOSE:The reaction of uridine with phosphorus oxychloride or oxybromide is conducted in dimethylformamide to enable 1-step preparation of the titled compound having antitumor activity without protection of uridine. CONSTITUTION:The objective compound of formula II (X is Cl or Br) is obtained by reaction of uridine or its derivative of formula I (R is H, halogen, 1- 4C alkyl) with phosphorus oxychloride or oxybromide in dimethylformamide, preferably at 50-100 deg.C for 1-5hr. The compounds of formula II other than 2', 5'-dichloro-2',5'-dideoxyuridine and 2',5'-dichloro-2',5'-dideoxy-5-fluorouridine are novel.
|
