| 摘要 |
NEW MATERIAL:A compound shown by the formula I [R1 is lower alkylsulfonyloxy, (substituted)arylsulfonyloxy, heterocyclic thio, (substituted)alkylthio, etc.; R2 is group shown by the formula II (R4 is phenyl, or 2-aminothiazolyl), etc.; R3 is H, alkali(earth) metal, ester residue, etc.]. EXAMPLE:(6R, 7S)-7[(R)-Phenylglycylamino]-3-( 1,2,3-thiadiazol-5-yl-thio )-1-azabicyclo[4,2,0]oct-2-en-8-oxo-2-carboxylic acid. USE:An antibacterial agent. PREPARATION:For example, 3-hydrocarbacephem compound is reacted with a sulfonic acid, then with sodium salt of 5-mercapto-1,2,3-thiadiazole, the reaction product is aminated at 7-position and simultaneously hydrolyzed, the amino group is further acylated, and the carboxyl group is esterified, to give a compound shown by the formula I . |
