Partially retro-inverted decapeptide as a specific renin inhibitor with high resistance to enzymatic hydrolysis

摘要

Synthesis of an analogue of the (5-14) decapeptide of equine angiotensinogen partially retro-inverted at the Phe-Phe bond, of formula: +TR The retro-inverso analogue inhibits renin with high resistance to enzymatic degradation, and can be used in the treatment of renin-dependent hypertension.