MODIFIED HYALURONATE HYDROPHILIC COMPOSITIONS, COATINGS AND METHODS

摘要

This invention relates to hydrophilic polymer compositions and a preferred application therefore, viz., hydrophilic medical device coatings. The hyaluronic acid hyaluronon by itself or modified as described herein advantageously reacts with compositions disclosed in U.S. Pat. No. 7,776,956 to produce hydrophilic compositions and coatings particularly useable with medical devices.

主权项

1. An HA-based composition, comprising the reaction product of:
a) an HA-compound selected from the group consisting of a hyaluronic acid, a hyaluronate, a hyaluronan, and salts thereof; and b) a water dispersible epoxy urethane (glycidyl carbamate) of formula I or II, or a self-crosslinked derivative thereof: wherein:
i) n ranges from 1 to 50;ii) R2 is independently an optionally substituted divalent C1-C15 alkyl, an optionally substituted divalent C13-C15 cycloalkyl, or a group selected from: and
iii) R3 is independently an optionally substituted C1-C15 alkyl.