发明名称 |
Process for producing of 4-(2-methoxyethyl)-phenylglycidyl ether and/or metoprolol. |
摘要 |
<p>A process for the preparation of metoprolol in a stereospecifice form or a pharmaceutically acceptable salt thereof like an acid addition salt, and/or a stereospecific form of 4-(2-methoxyethyl)-phenylglycidyl ether which comprises subjecting 4-(2-methoxyethyl)-phenylallyl ether to the action of a micro-organism having the ability for stereoselective epoxidation of 4-(2-methoxyethyl)-phenylallyl ether into 4-(2-methoxyethyl)-phenylglycidyl ether, having at least 80% by weight the S configuration, at least partly separating 4-(2-methoxyethyl)-phenylglycidyl ether with isopropylamine and at least partly separating metoprolol and/or converting metoprolol into the pharmaceutically acceptable salt thereof.</p> |
申请公布号 |
EP0193228(A1) |
申请公布日期 |
1986.09.03 |
申请号 |
EP19860200199 |
申请日期 |
1986.02.11 |
申请人 |
GIST - BROCADES N.V.;SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. |
发明人 |
PHILLIPS, GARETH THOMAS;ROBERTSON, BRIAN WILLIAM;BERTOLA, MAURO ATTILIO;KOGER, HEIN SIMON;MARX, ARTHUR FRIEDRICH;WATTS, PETER DOUGLAS |
分类号 |
C07D303/20;C07D301/02;C07D303/22;C07D303/24;C12P7/22;C12P13/00;C12P17/02;C12R1/01;C12R1/32;C12R1/365;C12R1/38;(IPC1-7):C07D303/24;C07C93/06 |
主分类号 |
C07D303/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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