| 摘要 |
A method of treatment of emesis, anxiety and/or IBS in mammals, including humans, which method comprises administering an effective amount of a compound of formula (I) or (II) or a pharmaceutically acceptable salt thereof:… Ar-CO-Y-Z (I)… wherein Ar is a group of formula (a): …<CHEM>… wherein:… R1 and R2 are independently selected from hydrogen, halogen, C1-6 alkyl, C1-4 alkoxy, hydroxy, amino optionally substituted by one or two C1-4 alkyl groups, thiol, C1-4 alkylthio; X is CH2, NR3, -O- or -S- wherein R3 is hydrogen, C1-4 alkyl, C3-5 alkenyl, phenyl or phenyl C1-4 alkyl;… or Ar is a group of formula (b): …<CHEM>… wherein R4 to R7 are independently hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, hydroxy, amino optionally substituted by one or two C1-4 alkyl, by C1-4 alkanoylamino or pyrrolyl, one of R4 to R7 being other than hydrogen;… Y is -O- or -NH-; and… Z is a group of formula (c), (d) or (e): …<CHEM>… wherein… n is 2, 3 or 4;… R8 is hydrogen, C1-7 alkyl, C3-5 alkenyl or phenyl C1-4 al |
