发明名称 |
GONADOLIBERIN DERIVATIVES CONTAINING AN AROMATIC AMINOCARBOXYLIC ACID IN THE 6-POSITION, PHARMACEUTICAL AND VETERINARY COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME |
摘要 |
The invention relates to novel gonadoliberin nonapeptide ethylamide or decapeptide amide derivatives of the general formula (I), Glp-His-Trp-Ser-Tyr-X1-X2-X3-Pro-X4 (I) wherein X1 stands for a 2-aminobenzoic or 3-aminobenzoic acid group; X2 stands for a leucyl, tryptophyl or phenylalanyl group; X3 means an arginyl, leucyl or glutaminyl group; and X4 represents a glycylamide or ethylamide group, as well as their acid addition salts and pharmaceutical presparations containing these compounds. Further on, the invention relates to a process for preparing these compounds and preparations. The gonadoliberin derivatives of the invention can more effectively be used for reproduction biological purposes as compared to the derivatives known so far. |
申请公布号 |
SE8700016(D0) |
申请公布日期 |
1987.01.02 |
申请号 |
SE19870000016 |
申请日期 |
1987.01.02 |
申请人 |
INNOFINANCE ALTALANOS INNOVACIOS PENZINTEZET |
发明人 |
1)A * HORVAATH;2)G * KERI;3)T * GULYAS;4)I * TEPLAN;5)S * VIGH;6)G * BOKONYI |
分类号 |
A61K38/04;A61K38/00;A61P15/00;C07K1/02;C07K1/04;C07K7/06;C07K7/23;C07K14/575;(IPC1-7):C07K/ |
主分类号 |
A61K38/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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