| 摘要 |
PURPOSE:To obtain the titled receptor having strong tumoricidal activity and useful as a remedy for cancer, by bonding a cytotoxic agent to a T-cell antigen receptor linkable specifically to a cell membrane antigen, especially to tumor cell. CONSTITUTION:For example, a T-cell antigen receptor (Japanese Patent Application No.60-92299) produced from a tumor-recognizing cloned T-cell is linked with a cytotoxic agent (e.g. cyclophosphamide, fluorouracil, bleomycin, etc.) to obtain the objective receptor. The linking can be carried out e.g. by preparing a complex composed of a carcinostatic agent such as adriamycin linked to a T-cell antigen receptor using dextran as a crosslinking agent. A strong tumoricidal activity can be imparted by linking a cytotoxic agent to a T-cell antigen receptor linkable specifically to a cell membrane antigen, especially to a tumor cell. |
