| 发明名称 |
DRY POWDER DRUG DELIVERY SYSTEM |
| 摘要 |
A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of endocrine disease, for example, diabetes and/or obesity. |
| 申请公布号 |
US2016287820(A1) |
申请公布日期 |
2016.10.06 |
| 申请号 |
US201615182503 |
申请日期 |
2016.06.14 |
| 申请人 |
MannKind Corporation |
发明人 |
Smutney Chad C.;Adamo Beniot;Polidoro John M.;Kinsey P. Spencer;Overfield Dennis;Sahi Carl R.;Billings Christine;Marino Mark T. |
| 分类号 |
A61M15/00;A61K38/28;A61K9/00 |
主分类号 |
A61M15/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A dry powder inhaler comprising:
a flow path through a container within the dry powder inhaler, wherein the container includes a dry powder formulation comprising a diketopiperazine, and wherein after a single inhalation the diketopiperazine in a subject's plasma has an AUC0-∞ greater than 2,300 ng*min/mL per mg of the diketopiperazine content in the dry powder formulation. |
| 地址 |
Valencia CA US |
