Labeled molecular imaging agents and methods of use

摘要

Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.

主权项

1. An imaging agent comprising a compound of Formula I wherein R is H or C1-C5 alkyl; Y is acyl or sulfonyl; A=null, —O—CH2—, —C2H4—, or —CH2—O— Ar=4-substituted phenyl, a 4-substituted naphthalene-1-yl, a 5-substituted naphthalene-1-yl, or a 6-substituted naphthalene-1-yl; X is 18F, 3H, —(CH2)mZ, or —O—(CH2)mZ, Z is 18F or 3H; n is an integer between 1 and 3; and m is an integer between 1 and 5.