Melatonin-based treatment and diagnosis of bile duct disease

摘要

Methods and composition for a melatonin signaling modulator-based diagnosis and therapy are described. For example, in certain aspects methods for administering an anti-tumor therapy using a melatonin signaling modulator are described. Furthermore, the invention provides compositions and methods for detecting biliary tract disease such as cholangiocarcinoma.

主权项

1. A method for treating biliary hyperplasia, cholestasis, cholangiopathy, cholangiocarcinoma, primary biliary cirrhosis (PBC) or primary sclerosing cholangitis (PSC) in a subject, comprising administering to the subject in need thereof a pharmaceutically effective amount of one or more agents selected from the group consisting of:
i) an exogenous AANAT (aralkylamine N-acetyltransferase) expression cassette, ii) an exogenous ASMT (acetylserotonin O-methyltransferase) expression cassette, iii) an exogenous Per1 (period circadian protein homolog 1) expression cassette, iv) an exogenous Bmal1 (brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT)-like) inhibitory nucleic acid or nucleic acid analog, v) an exogenous CLOCK (Circadian Locomotor Output Cycles Kaput) expression cassette, and vi) melatonin, wherein the proliferation of cholangiocytes in the subject is inhibited.