Lipopolysaccharide-Targeted Peptide Mimic Vaccine Against Q Fever

摘要

A vaccine and method of vaccination for conferring immunity to Q fever is described. The vaccine comprises a polypeptide with a sequence of SLTWHKHELHRK (m1E41920) or SPPWHKHELHRK (m1E44), or at least 90% identity to m1E41920 or m1E44. Constructs are also provided for use in vaccination and treatment of Q fever. A method to identify and generate new vaccines to prevent diseases caused by intracellular Gram-negative bacteria is also described.

主权项

1. An isolated humanized antibody or antigen-binding fragment thereof for protection against gram negative intracellular bacterial infection, that specifically binds to a lipopolysaccharide-based epitope in gram negative bacteria, wherein the humanized antibody or antigen-binding fragment thereof competes for binding to a lipopolysaccharide-based peptide mimetic sequence of SLTWHKHELHRK (SEQ ID NO: 7) or SPPWHKHELHRK (SEQ ID NO: 8), or a peptide sequence having at least 90% identity to SLTWHKHELHRK (SEQ ID NO: 7) or SPPWHKHELHRK (SEQ ID NO: 8), or pharmaceutically acceptable salt thereof.